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Disease & Health⏱️ 8 min read•Verified by ICAR-NDRI Clinical Medicine Specialist & KisanPe Editorial

Milk Fever (Hypocalcemia) & Ketosis: Calcium Borogluconate Therapy & DCAD Diet

मिल्क फीवर (दुग्ध ज्वर) और कीटोसिस: कैल्शियम थेरेपी, लक्षण और रोकथाम

Executive Summary & Operational Context

Milk Fever (acute hypocalcemia) and Ketosis (acetonemia) are the twin metabolic nightmares that strike high-yielding dairy cows within 48 hours to 4 weeks of calving. Prompt intravenous calcium and oral propylene glycol can bring a downer, comatose cow to her feet in 20 minutes.

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Field Master Rule

Administering 450 mL of warm 25% Calcium Borogluconate intravenously at a controlled heart rate restores neuromuscular function and stands up a downer cow.

Milk Fever Window
0 to 48 Hrs Post-Calving
Sudden colostrum calcium drain
Ketosis Window
10 to 30 Days Post-Calving
Negative Energy Balance (NEB)
Emergency IV Solution
Calcium Borogluconate 25%
Slow IV infusion over 15 min
Ketosis Antidote
Propylene Glycol (250 mL)
Oral glucogenic precursor

Clinical Signs of Stage 2 & Stage 3 Milk Fever

Despite its name, Milk Fever causes sub-normal hypothermic body temperature (97–100°F), not a fever! Stage 1: Trembling, excitability, stiff gait. Stage 2 (Sternal Recumbency): The cow cannot stand up; sits with her neck kinked in an "S-curve" or her head resting on her flank, cold ears and muzzle, dry nose, and dilated pupils. Stage 3 (Lateral Recumbency): Cow lies flat on her side, completely comatose and bloats rapidly; without urgent intravenous calcium, death from cardiac arrest occurs within hours.

Actionable Implementation Checklist

How to Implement on Your Dairy Farm

1

Warm Calcium Borogluconate to Body Temp

Always warm the 450 mL glass bottle of 25% Calcium Borogluconate in warm water to 38°C before IV infusion to prevent cardiac shock.

2

Infuse Slowly Over 15–20 Minutes

Auscultate the heart continuously during IV infusion. If heart rate skips or accelerates dangerously, stop infusion temporarily.

3

Drench Oral Calcium Gel

Administer an oral ionic calcium paste (Cal-Up / Animate gel) 12 hours after the IV infusion to maintain continuous blood calcium levels.

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Continuous Learning

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FAQ

Frequently Asked Questions: Milk Fever (Hypocalcemia) & Ketosis: Calcium Borogluconate Therapy & DCAD Diet

During severe negative energy balance, the liver breaks down body fat into ketone bodies (acetone, acetoacetate, beta-hydroxybutyrate). Volatile acetone is expelled through the lungs, giving the cow's breath, milk, and urine a sweet, sickly fruity/nail-polish remover aroma.

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