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Crop Protection & Pesticides

Azadirachtin: Neem Bio-Insecticide, Pests and Safety

Azadirachtin is the principal limonoid active ingredient extracted from the seed kernels of the neem tree (Azadirachta indica). Formulated commercially as emulsifiable concentrates ranging from 300 ppm (0.03%) up to 50,000 ppm (5.0%), it provides eco-friendly broad-spectrum pest suppression with zero toxic chemical residues on food crops.

Last reviewed: 10 November 2026

Botanical modes of action against insect pests

Azadirachtin possesses complex physiological modes of action that prevent insects from developing resistance. It functions as a powerful antifeedant, causing pests to starve even in the presence of foliage. Furthermore, it disrupts ecdysone hormone titers, arresting insect molting and preventing larvae from pupating into viable adults.

  • Antifeedant and deterrent: Deters feeding and oviposition by chewing and sucking pests.
  • Insect Growth Regulator (IGR): Disrupts juvenile hormone and ecdysone, causing mortal deformities during insect molts.
  • Repellent action: Natural volatile compounds repel adult moths and beetles from laying eggs on crops.

Target insect complexes across crops

  • Vegetables and horticulture: Whiteflies, aphids, thrips, and diamondback moth caterpillars.
  • Paddy and cotton: Brown plant hoppers, leaf folders, bollworms, and jassids.
  • Pulses and oilseeds: Pod borers, leaf miners, and hairy caterpillars.

Safe application and organic certification

Azadirachtin is safe for beneficial predators including ladybird beetles, spiders, and honeybees once spray deposits dry. It is universally approved for certified organic farming under the National Programme for Organic Production (NPOP). Apply in late afternoon to minimize UV photolysis of the natural limonoid compound.

Official source

Check the latest rules, benefits and forms here. KisanPe is an independent platform and is not a government website.

Central Insecticides Board & Registration Committee ↗

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Common questions

How does Azadirachtin kill insect pests?

It acts primarily as an antifeedant and insect growth regulator, halting insect feeding and preventing immature larvae from molting.

Is Azadirachtin safe for honeybees and earthworms?

Yes, natural neem formulations have an exceptionally favorable safety profile for earthworms, birds, and adult honeybees.

What concentrations of Azadirachtin are available in India?

Commercial CIBRC-registered formulations range from 300 ppm (0.03%), 1500 ppm (0.15%), 10000 ppm (1%), up to 50000 ppm (5%).

General guidance, not personal advice. For your farm, ask your local Krishi Vigyan Kendra or agriculture officer.

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