Chemical Class & Novel Mode of Action
Isocycloseram belongs to the novel isoxazoline chemical family. It represents a breakthrough in chemical innovation, assigned to IRAC Group 30.
It binds to an allosteric site on insect GABA (gamma-aminobutyric acid) receptors in insect central nervous systems. By preventing normal inhibitory GABA nerve signaling, it causes uncontrollable nervous hyperexcitation, paralysis, and death in target pests.
- Active Molecule: Isocycloseram (developed by Syngenta)
- IRAC Classification: Group 30 (GABA-gated chloride channel allosteric modulators)
- Resistance Breakthrough: Zero cross-resistance to existing organophosphates, pyrethroids, neonicotinoids, or diamides
- Action Spectrum: Broad control of caterpillars, thrips, leafminers, beetles, and phytophagous mites
Target Pests & Crop Spectrum in India
Isocycloseram is registered under the CIBRC in commercial products (such as Incipio and Simodis) for managing challenging pest complexes in rice, cotton, chillies, tomatoes, and vegetables.
In paddy, it provides exceptional, long-lasting control of yellow stem borer and leaf folder caterpillars, while in vegetables it provides outstanding suppression of invasive thrips (including Thrips parvispinus).
- Rice (Incipio): Controls yellow stem borer (Scirpophaga incertulas) and leaf folder (Cnaphalocrocis medinalis)
- Chillies & Vegetables (Simodis): Powerful management of resistant thrips, fruit borers, and mites
- Residual Control: Provides extended protection up to 14 to 21 days due to robust photostability on leaf surfaces
- Translaminar Movement: Penetrates leaf tissues to manage hidden leafminer larvae and thrips hiding under leaves
Application Guidelines & Resistance Management
Because Isocycloseram is a valuable resistance-breaking tool, agricultural universities and IRAC mandate strict resistance stewardship to protect its long-term field efficacy.
Apply at economic threshold triggers using recommended water volumes. Never exceed labeled application frequencies per crop cycle, and rotate with alternate IRAC modes of action.
- Application Timing: Spray during early caterpillar egg hatch or initial pest migration into crops
- Water Volume: Use 200 liters of water per acre for field crops, ensuring uniform fine droplet coverage
- Waiting Period: Comply with statutory pre-harvest intervals (PHI) declared on the CIBRC approved product packaging
- Personal Safety: Wear chemical-resistant gloves, face shield, and protective apron during tank mixing
Official source
Check the latest rules, benefits and forms here. KisanPe is an independent platform and is not a government website.
Central Insecticides Board & Registration Committee (CIBRC) ↗Related on KisanPe
Common questions
What is the commercial brand name of Isocycloseram in India?
Syngenta markets Isocycloseram under the PLINAZOLIN technology platform, featured in products such as Incipio (for paddy) and Simodis (for vegetables and chillies).
Why is Isocycloseram considered a resistance breakthrough?
Because it belongs to IRAC Group 30 with a novel target site on GABA receptors; pests that have become resistant to neonicotinoids, pyrethroids, or diamides remain completely susceptible to it.
How does Isocycloseram move within the plant?
It possesses strong translaminar movement, penetrating through the leaf surface to control pests feeding on the underside of foliage and within leaf layers.
General guidance, not personal advice. For your farm, ask your local Krishi Vigyan Kendra or agriculture officer.
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